Pezzati, Bernardo and Chellat, Mathieu F. and Murphy, John J. and Besnard, Céline and Reginato, Gianna and Stephens, John C. and Alexakis, Alexandre (2013) Organocatalytic Asymmetric Annulation of 1,3-Bis(alkoxycarbonyl)buta-1,3-dienes and Aldehydes. Organic Letters, 15 (12). pp. 2950-2953. ISSN 1523-7060

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Abstract

Asymmetric organocatalytic annulation of E/Z isomeric mixtures of bis(alkyl carboxylate)buta-1,3-dienes and aldehydes has been realized via enamine catalysis. In the presence of R,R-diphenyl-2-pyrrolidinemethanol trimethylsilyl ether, excellent stereo- and enantioselectivities were achieved for a broad spectrum of substrates.

Item Type:	Article
Keywords:	Organocatalytic Asymmetric Annulation; bis(alkyl carboxylate)buta-1; 3-dienes; aldehydes; enamine catalysis;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	7703
Identification Number:	https://doi.org/10.1021/ol401042b
Depositing User:	Dr John Stephens
Date Deposited:	10 Jan 2017 15:06
Journal or Publication Title:	Organic Letters
Publisher:	American Chemical Society
Refereed:	Yes
URI:	http://pubs.acs.org
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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