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    C-3β-Tethered Functional Cholesterol Conjugates by Nitrile Oxide Alkyne Cycloaddition (NOAC)


    Algay, Virginie and O'Sullivan, Justine and Heaney, Frances (2014) C-3β-Tethered Functional Cholesterol Conjugates by Nitrile Oxide Alkyne Cycloaddition (NOAC). European Journal of Organic Chemistry, 2014 (12). pp. 2522-2532. ISSN 1434-193X

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    Abstract

    Covalent cholesterol conjugates have been prepared by isoxazole-generating [3+2] nitrile oxide alkyne cycloaddition (NOAC) chemistry. Steroidal building blocks functionalised with either an alkyne or a nitrile oxide precursor were evaluated. The reaction has been demonstrated for the tethering to cholesterol of groups capable of bioreporting, and for the formation of cholesterol–biomolecule conjugates.

    Item Type: Article
    Keywords: Steroids; Lipids; Cycloaddition; Alkynes; Heterocycles; Conjugation;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 7738
    Identification Number: https://doi.org/10.1002/ejoc.201301822
    Depositing User: Dr. Frances Heaney
    Date Deposited: 13 Jan 2017 14:24
    Journal or Publication Title: European Journal of Organic Chemistry
    Publisher: Wiley
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI), Irish Research Council for Science Engineering and Technology (IRCSET)
    URI:

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