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Algay, Virginie, O'Sullivan, Justine and Heaney, Frances (2014) C-3β-Tethered Functional Cholesterol Conjugates by Nitrile Oxide Alkyne Cycloaddition (NOAC). European Journal of Organic Chemistry, 2014 (12). pp. 2522-2532. ISSN 1434-193X
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Abstract
Covalent cholesterol conjugates have been prepared by isoxazole-generating [3+2] nitrile oxide alkyne cycloaddition (NOAC) chemistry. Steroidal building blocks functionalised with either an alkyne or a nitrile oxide precursor were evaluated. The reaction has been demonstrated for the tethering to cholesterol of groups capable of bioreporting, and for the formation of cholesterol–biomolecule conjugates.
| Item Type: | Article |
|---|---|
| Keywords: | Steroids; Lipids; Cycloaddition; Alkynes; Heterocycles; Conjugation; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 7738 |
| Identification Number: | 10.1002/ejoc.201301822 |
| Depositing User: | Dr. Frances Heaney |
| Date Deposited: | 13 Jan 2017 14:24 |
| Journal or Publication Title: | European Journal of Organic Chemistry |
| Publisher: | Wiley |
| Refereed: | Yes |
| Funders: | Science Foundation Ireland (SFI), Irish Research Council for Science Engineering and Technology (IRCSET) |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/7738 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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