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    Observation of a Rectangular Columnar Phase in a DNA−Calcium−Zwitterionic Lipid Complex


    McManus, Jennifer and Rädler, Joachim O. and Dawson, Kenneth A. (2004) Observation of a Rectangular Columnar Phase in a DNA−Calcium−Zwitterionic Lipid Complex. Journal of the American Chemical Society, 126 (49). pp. 15966-15967. ISSN 0002-7863

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    Abstract

    In the presence of calcium, DNA and unilamellar liposomes of the zwitterionic lipid DPPC form a complex in which DNA strands are embedded between a lamellar phase of DPPC. In some complexes, in-plane alignment of the DNA strands occurs, where a DNA-DNA interaxial distance can be measured using small-angle X-ray scattering. Here we report a higher level of DNA organization, with a rectangular columnar phase of DNA identified within this complex structure. This observation is important in view of recent interests in creating new synthetic systems at the interface of biology.

    Item Type: Article
    Keywords: Rectangular Columnar Phase; DNA−Calcium−Zwitterionic Lipid Complex; DNA; Calcium;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 7897
    Identification Number: https://doi.org/10.1021/ja046105+
    Depositing User: Jennifer McManus
    Date Deposited: 10 Feb 2017 15:45
    Journal or Publication Title: Journal of the American Chemical Society
    Publisher: American Chemical Society
    Refereed: Yes
    URI:

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