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McManus, Jennifer, Rädler, Joachim O. and Dawson, Kenneth A. (2004) Observation of a Rectangular Columnar Phase in a DNA−Calcium−Zwitterionic Lipid Complex. Journal of the American Chemical Society, 126 (49). pp. 15966-15967. ISSN 0002-7863
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Abstract
In the presence of calcium, DNA and unilamellar liposomes of the zwitterionic lipid DPPC form a complex in which DNA strands are embedded between a lamellar phase of DPPC. In some complexes, in-plane alignment of the DNA strands occurs, where a DNA-DNA interaxial distance can be measured using small-angle X-ray scattering. Here we report a higher level of DNA organization, with a rectangular columnar phase of DNA identified within this complex structure. This observation is important in view of recent interests in creating new synthetic systems at the interface of biology.
| Item Type: | Article |
|---|---|
| Keywords: | Rectangular Columnar Phase; DNA−Calcium−Zwitterionic Lipid Complex; DNA; Calcium; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 7897 |
| Identification Number: | 10.1021/ja046105+ |
| Depositing User: | Jennifer McManus |
| Date Deposited: | 10 Feb 2017 15:45 |
| Journal or Publication Title: | Journal of the American Chemical Society |
| Publisher: | American Chemical Society |
| Refereed: | Yes |
| Related URLs: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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