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    The synthesis of 1,2,7,11b-Tetrahydroisoxazolo[2,3-d][1,4]benzodiazepin-6(5H)-ones and 1,3,3a,9b-tetrahydroisoxazolo[4,3-c]quinolin-4(5H)-ones


    Heaney, Frances and Bourke, Sharon (1995) The synthesis of 1,2,7,11b-Tetrahydroisoxazolo[2,3-d][1,4]benzodiazepin-6(5H)-ones and 1,3,3a,9b-tetrahydroisoxazolo[4,3-c]quinolin-4(5H)-ones. Tetrahedron Letters, 36 (41). pp. 7527-7530. ISSN 0040-4039

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    Abstract

    The reaction of various ethyl 3-[[2-(1-hydroxyiminoalkyl)phenyl]carbamoyl]acrylates (2) with electron deficient olefins proceeds via a sequential dipole formation, dipolar cycloaddition sequence to furnish the tetrahydroisoxazolo[2,3-d][1,4]benzodiazepin-6(5H)-ones and tetrahydroisoxazolo[4,3-c]quinolin-4(5H)-ones (4) and (6). The product distribution reflects the nature of the reacting olefin and the position and extent of substitution on the acrylate moiety.

    Item Type: Article
    Keywords: synthesis; 1,2,7,11b-Tetrahydroisoxazolo[2,3-d][1,4]benzodiazepin-6(5H)-ones; 1,3,3a,9b-tetrahydroisoxazolo[4,3-c]quinolin-4(5H)-ones; ethyl 3-[[2-(1-hydroxyiminoalkyl)phenyl]carbamoyl]acrylates;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 7970
    Identification Number: https://doi.org/10.1016/0040-4039(95)01523-X
    Depositing User: Dr. Frances Heaney
    Date Deposited: 24 Feb 2017 16:30
    Journal or Publication Title: Tetrahedron Letters
    Publisher: Elsevier
    Refereed: Yes
    URI:

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