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    Evidence for uncoupling of oxygen and glucose utilization during neuronal activation in rat striatum


    Lowry, John P. and Fillenz, Marianne (1997) Evidence for uncoupling of oxygen and glucose utilization during neuronal activation in rat striatum. Journal of Physiology, 498 (2). pp. 497-501. ISSN 0022-3751

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    Abstract

    1. Changes in regional cerebral blood flow (rCBF), tissue oxygen and extracellular glucose were measured during neuronal activation, using implanted electrodes in the striatum of freely moving rats. 2. There was a parallel increase in rCBF and oxygen in response to neuronal activation. 3. During the neuronal activation there was a decrease in extracellular glucose; following neuronal activation there was a slow rise in extracellular glucose which took 30 min to return to basal levels. 4. The implications of the different time courses of these changes are discussed.

    Item Type: Article
    Additional Information: This manuscript was accepted as a Short Paper for rapid publication.
    Keywords: uncoupling; oxygen; glucose utilization; neuronal activation; rat striatum;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 8063
    Depositing User: John Lowry
    Date Deposited: 24 Mar 2017 13:29
    Journal or Publication Title: Journal of Physiology
    Publisher: Physiological Society
    Refereed: Yes
    URI:

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