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    The Branching Point in Erythro-Myeloid Differentiation

    Perie, Leila and Duffy, Ken R. and Kok, Lianne and de Boer, Rob J. and Schumacher, Ton N. (2015) The Branching Point in Erythro-Myeloid Differentiation. Cell, 163. pp. 1655-1662. ISSN 0092-8674

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    Development of mature blood cell progenies from hematopoietic stem cells involves the transition through lineage-restricted progenitors. The first branching point along this developmental process is thought to separate the erythro-myeloid and lymphoid lineage fate by yielding two intermediate progenitors, the common myeloid and the common lymphoid progenitors (CMPs and CLPs). Here, we use single-cell lineage tracing to demonstrate that so-called CMPs are highly heterogeneous with respect to cellular output, with most individual CMPs yielding either only erythrocytes or only myeloid cells after transplantation. Furthermore, based on the labeling of earlier progenitors, we show that the divergence between the myeloid and erythroid lineage develops within multipotent progenitors (MPP). These data provide evidence for a model of hematopoietic branching in which multiple distinct lineage commitments occur in parallel within the MPP pool.

    Item Type: Article
    Keywords: Branching Point; Erythro-Myeloid Differentiation;
    Academic Unit: Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Item ID: 8192
    Identification Number:
    Depositing User: Dr Ken Duffy
    Date Deposited: 04 May 2017 08:49
    Journal or Publication Title: Cell
    Publisher: Elsevier (Cell Press)
    Refereed: Yes

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