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    Synthesis, characterization and antimicrobial activity of a series of substituted coumarin-3-carboxylatosilver(1) complexes


    Creaven, Bernadette and Egan, Denise and Kavanagh, Kevin and McCann, Malachy and Noble, Andy and Thati, Bhumika and Walsh, Maureen (2006) Synthesis, characterization and antimicrobial activity of a series of substituted coumarin-3-carboxylatosilver(1) complexes. Inorganica Chimica Acta, 359 (12). pp. 3976-3984.

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    Abstract

    A series of new coumarin-derived carboxylate ligands and their silver(I) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against a range of Gram-positive and Gram-negative bacteria as well as for their antifungal activity against a clinical isolate of Candida albicans. The ligands were synthesised by either acid or base hydrolysis of their corresponding esters, which in turn were synthesised via the Knoevenegal reaction. The reaction of silver(I) nitrate with the coumarin carboxylate ligands in either aqueous or aqueous/ethanol solutions allowed the isolation of a series of novel Ag(I) carboxylate complexes. Whilst none of the ligands showed any antimicrobial activity, a number of the Ag(I) complexes exhibited potent activity. In particular, Ag(I) complexes of hydroxy-substituted coumarin carboxylates demonstrated potent activity against the clinically important methicillin-resistant Staphylococcus aureus (MRSA) bacterium (MIC80 = 0.63 μM).

    Item Type: Article
    Keywords: Synthesis; antimicrobial; coumarin; carboxylatosilver;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 904
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 21 Feb 2008
    Journal or Publication Title: Inorganica Chimica Acta
    Publisher: Elsevier
    Refereed: Yes
    URI:

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