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    Resistance is not futile: gliotoxin biosynthesis, functionality and utility


    Dolan, Stephen K. and O'Keefe, Grainne and Jones, Gary W. and Doyle, Sean (2015) Resistance is not futile: gliotoxin biosynthesis, functionality and utility. Trends in Microbiology, 23 (7). pp. 419-428. ISSN 0966-842X

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    Abstract

    Gliotoxin biosynthesis is encoded by the gli gene cluster in Aspergillus fumigatus. The biosynthesis of gliotoxin is influenced by a suite of transcriptionally-active regulatory proteins and a bis-thiomethyltransferase. A self-protection system against gliotoxin is present in A. fumigatus. Several additional metabolites are also produced via the gliotoxin biosynthetic pathway. Moreover, the biosynthesis of unrelated natural products appears to be influenced either by gliotoxin or by the activity of specific reactions within the biosynthetic pathway. The activity of gliotoxin against animal cells and fungi, often mediated by interference with redox homeostasis or protein modification, is revealing new metabolic interactions within eukaryotic systems. Nature has provided a most useful natural product with which to reveal some of its many molecular secrets

    Item Type: Article
    Keywords: Aspergillus fumigatus; NRPS; natural products; secondary metabolism; antioxidant;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 9133
    Identification Number: /10.1016/j.tim.2015.02.005
    Depositing User: Dr. Sean Doyle
    Date Deposited: 09 Jan 2018 14:56
    Journal or Publication Title: Trends in Microbiology
    Publisher: Elsevier
    Refereed: Yes
    URI:

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