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    Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity.


    Creaven, Bernadette S. and Devereux, Michael and Karcz, Dariusz and Kellett, Andrew and McCann, Malachy and Noble, Andy and Walsh, Maureen (2009) Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity. Journal of Inorganic Biochemistry, 103. pp. 1196-1203. ISSN 0162-0134

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    Abstract

    The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper( II) acetate yielded Cu(II) complexes (3a–3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.

    Item Type: Article
    Keywords: Copper; Metal complexes; X-ray crystal structures; Antifungal;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 9678
    Depositing User: Dr. Malachy McCann
    Date Deposited: 13 Jul 2018 12:28
    Journal or Publication Title: Journal of Inorganic Biochemistry
    Publisher: Elsevier
    Refereed: Yes
    URI:

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