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Creaven, Bernadette S., Devereux, Michael, Karcz, Dariusz, Kellett, Andrew, McCann, Malachy, Noble, Andy and Walsh, Maureen (2009) Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity. Journal of Inorganic Biochemistry, 103. pp. 1196-1203. ISSN 0162-0134
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Official URL: https://www.journals.elsevier.com/journal-of-inorg...
Abstract
The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes
yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper(
II) acetate yielded Cu(II) complexes (3a–3k) and some were characterised using X-ray crystallography.
All of the free ligands and their metal complexes were tested for their anti-Candida activity. A
number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially
available antifungal drugs, ketoconazole and Amphotericin B.
| Item Type: | Article |
|---|---|
| Keywords: | Copper; Metal complexes; X-ray crystal structures; Antifungal; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 9678 |
| Depositing User: | Dr. Malachy McCann |
| Date Deposited: | 13 Jul 2018 12:28 |
| Journal or Publication Title: | Journal of Inorganic Biochemistry |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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