Commins, Sean and Farina, Francesca (2016) Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism. Behavioural Brain Research, 307. pp. 194-198. ISSN 0166-4328

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Abstract

The objective of this study was to examine the effects of NMDAR and AMPAR antagonism on the expression of Zif268 and c-Fos in the hippocampus and medial prefrontal cortex during spatial memory encoding in rats trained in the Morris water maze. NMDAR inhibition impaired navigation and significantly attenuated expression of Zif268, but not c-Fos, in area CA1. AMPAR channel blockade had little effect on learning or IEG expression. Overall, Zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with Zif268 being more closely linked to spatial learning.

Item Type:	Article
Keywords:	Glutamate receptors; Immediate early genes; Hippocampus; Prefrontal cortex; Spatial memory;
Academic Unit:	Faculty of Science and Engineering > Psychology
Item ID:	10693
Identification Number:	https://doi.org/10.1016/j.bbr.2016.04.002
Depositing User:	Dr. Sean Commins
Date Deposited:	05 Apr 2019 16:25
Journal or Publication Title:	Behavioural Brain Research
Publisher:	Elsevier
Refereed:	Yes
URI:	https://www.sciencedirect.com
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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