Shawa, Kendra N. and Commins, Sean and O'Mara, Shane (2005) Cyclooxygenase inhibition attenuates endotoxin-induced spatial learning deficits, but not an endotoxin-induced blockade of long-term potentiation. Brain Research, 1038 (2). pp. 231-237. ISSN 0006-8993

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Abstract

Peripheral administration of lipopolysaccharide (LPS), a potent bacterial endotoxin, can cause a variety of central effects, including production of cytokines and cyclooxygenases in the brain, as well as peripheral increases in corticosterone. These, in turn, may contribute to neuroimmune-induced neurocognitive deficits. We show here LPS causes deficits in hippocampal-dependent spatial learning in the water maze but that treatment with ibuprofen, a broad-spectrum cyclooxygenase inhibitor, reverses the deficits induced in spatial learning by LPS. We also show that LPS causes an impairment in the induction of long-term potentiation in the dentate gyrus in vivo, a major contemporary model of learning and memory. No differences were found in corticosterone levels in trunk blood but we find a decrease in brain-derived neurotrophic factor (BDNF) expression in LPS group compared to saline controls. Paradoxically compared to the behavioral findings treatment with ibuprofen does not attenuate the LPS-induced impairment in LTP or BDNF concentration in tetanized tissue.

Item Type:	Article
Keywords:	Cyclooxygenase inhibition; Lipopolysaccharide; Long-term potentiation;
Academic Unit:	Faculty of Science and Engineering > Psychology
Item ID:	10716
Identification Number:	/10.1016/j.brainres.2005.01.035
Depositing User:	Dr. Sean Commins
Date Deposited:	10 Apr 2019 14:54
Journal or Publication Title:	Brain Research
Publisher:	Elsevier
Refereed:	Yes
Funders:	European Commission (EC), Health Research Board (HRB)
URI:	https://www.sciencedirect.com
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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