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    Chronotherapeutics and psychiatry: Setting the clock to relieve the symptoms

    Coogan, Andrew and Thome, Johannes (2011) Chronotherapeutics and psychiatry: Setting the clock to relieve the symptoms. World Journal of Biological Psychiatry, 12 (Supp.1). pp. 40-43. ISSN 1814-1412

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    Circadian rhythms are near 24-h cycles in a number of physiological and behavioural parameters and the underpinning circadian timing systems is one of the key homeostatic regulatory systems in mammalian physiology. Many common psychiatric conditions are associated with disrupted sleep, including a common occurrence of delayed or advanced phase sleep syndromes, which in themselves may be indicative of dysregulated circadian timing in these disorders. In this article we discuss the evidence for abnormal circadian rhythms in seasonal affective disorder, bipolar disorder and attention deficit/hyperactivity disorder. Much of this evidence suggest that these conditions are associated with either phase delays or phase advances of core phase markers of the circadian clock such as melatonin or core body temperature, suggesting the presence of circadian desynchrony in these conditions. We also highlight findings that pharmacological and/or behavioural interventions that ameliorate circadian misalignments are efficacious in producing symptomatic relief, suggesting an intrinsic link between the circadian and affective systems that can be manipulated for clinical benefit.

    Item Type: Article
    Keywords: Circadian; depression; chronotherapeutics;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 10724
    Identification Number:
    Depositing User: Dr. Andrew Coogan
    Date Deposited: 15 Apr 2019 14:20
    Journal or Publication Title: World Journal of Biological Psychiatry
    Publisher: Taylor & Francis
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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