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    Chronobiology and Chronotherapy of Affective Disorders

    Coogan, Andrew (2013) Chronobiology and Chronotherapy of Affective Disorders. Journal of Cognitive & Behavioral Psychotherapies, 13 (1a). pp. 239-254. ISSN 1584-7101

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    Circadian rhythms are recurring cycles across a range of behavioural, physiological and cognitive domains that display periods of approximately twenty four hours and are generated by an endogenous circadian timing system. In this review we examine the evidence that circadian rhythms are disrupted in affective disorders such as major depression, bipolar disorder and seasonal affective disorder, and examine what the nature of such circadian dysfunction may be. Further, we examine the evidence that chronotherapeutic interventions (both behavioural and pharmacological) that address underlying abnormalities of circadian phase in patients with affective disorders may produce rapid onset and long-lasting symptom relief. We conclude that there is promising data in the literature to support the utility of drawing on a considerable body of neuroscientific knowledge of circadian clock fundamentals to design and implement chronotherapeutic interventions in major affective disorders, but that there is also a need for a more systematic approach involving larger scale studies.

    Item Type: Article
    Keywords: Circadian; affective; chronotherapy; depression; bipolar; sleep;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 10730
    Depositing User: Dr. Andrew Coogan
    Date Deposited: 16 Apr 2019 14:14
    Journal or Publication Title: Journal of Cognitive & Behavioral Psychotherapies
    Publisher: International Institute for the Advanced Studies of Psychotherapy and Applied Mental Health
    Refereed: Yes
      Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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