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    Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

    Kelada, Mark and Walsh, John M.D. and Devine, Robert and McArdle, Patrick and Stephens, John C. (2018) Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation. Beilstein Journal of Organic Chemistry, 14. pp. 1222-1228. ISSN 1860-5397

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    A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.

    Item Type: Article
    Additional Information: This is an Open Access article under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cite as: Kelada, M.; Walsh, J. M. D.; Devine, R. W.; McArdle, P.; Stephens, J. C. Beilstein J. Org. Chem. 2018, 14, 1222–1228. doi:10.3762/bjoc.14.104
    Keywords: microwave-assisted synthesis; nitrogen-fused heterocycle; one-pot; pyrimidinone;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 10745
    Identification Number:
    Depositing User: Dr John Stephens
    Date Deposited: 24 Apr 2019 13:59
    Journal or Publication Title: Beilstein Journal of Organic Chemistry
    Publisher: Beilstein-Institut
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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