Montagner, Diego and Fresch, B. and Browne, K. and Gandin, Valentina and Erxleben, Andrea
(2017)
A Cu(II) complex targeting the translocator protein: in vitro
and in vivo antitumor potential and mechanistic insights.
Chemical Communications, 53 (1).
pp. 134-137.
ISSN 1364-548X
Abstract
A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.
| Item Type: |
Article
|
| Keywords: |
Cu(II) complex; translocator protein; antitumor potential; |
| Academic Unit: |
Faculty of Science and Engineering > Chemistry |
| Item ID: |
10753 |
| Identification Number: |
https://doi.org/10.1039/C6CC08100B |
| Depositing User: |
Diego Montagner
|
| Date Deposited: |
26 Apr 2019 14:00 |
| Journal or Publication Title: |
Chemical Communications |
| Publisher: |
Royal Society of Chemistry |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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