Palsson, Erik and Finnerty, Niall J. and Fejgin, Kim and Klamer, Daniel and Wass, Caroline and Svensson, Lennart and Lowry, John P. (2009) Increased Cortical Nitric Oxide Release After Phencyclidine Administration. Synapse, 63. pp. 1083-1088. ISSN 1098-2396

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Abstract

Phencyclidine exerts psychotomimetic effects in humans and is used as a pharmacological animal model for schizophrenia. We, and others, have demonstrated that phencyclidine induces cognitive deficits in rats that are associated with schizophrenia. These cognitive deficits can be normalized by inhibition of nitric oxide synthase. The development of selective microelectrochemical nitric oxide sensors may provide direct evidence for the involvement of nitric oxide in these effects. The aim of the present study was to use LIVE (long term in vivo electrochemistry) to investigate the effect of phencyclidine, alone or in combination with the nitric oxide synthase inhibitor L-NAME, on nitric oxide levels in the medial prefrontal cortex of freely moving rats. Phencyclidine (2 mg kg21) produced an increase in cortical nitric oxide levels and this increase was ameliorated by L-NAME (10 mg kg21). Tentatively, the results from the present study provide a biochemical rationale for the involvement of nitric oxide in the phencyclidine model of schizophrenia.

Item Type:	Article
Keywords:	rat; schizophrenia; in vivo voltammetry; cognition;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	10764
Identification Number:	https://doi.org/10.1002/syn.20690
Depositing User:	Niall Finnerty
Date Deposited:	30 Apr 2019 14:37
Journal or Publication Title:	Synapse
Publisher:	Wiley
Refereed:	Yes
URI:	https://onlinelibrary.wiley.com
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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