Kelly, Rachael M. and Healy, Ultan and Sreenan, Seamus and McDermott, John H. and Coogan, Andrew (2018) Clocks in the clinic: circadian rhythms in health and disease. Postgraduate Medical Journal, 94 (1117). pp. 653-658. ISSN 1469-0756

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Abstract

Circadian rhythms are endogenously generated recurring patterns of around 24 hours with well-established roles in physiology and behaviour. These circadian clocks are important in both the aetiology and treatment of various psychiatric and metabolic diseases. To maintain physiological homeostasis and optimal functioning, living life synchronised to these clocks is desirable; modern society, however, promotes a '24/7' lifestyle where activity often occurs during the body’s 'biological night', resulting in mistimed sleep and circadian misalignment. This circadian desynchrony can increase the risk of disease and can also influence treatment response. Clinicians should be aware of the influence that circadian desynchrony can have on health and disease, in order to potentially develop new therapeutic strategies and to incorporate chronotherapeutics into current treatment strategies to enhance their utility.

Item Type:	Article
Additional Information:	Cite as: Kelly RM, Healy U, Sreenan S, et al. Postgrad Med J 2018; 94:653–658
Keywords:	circadian rhythms; health; disease; circadian desynchrony; chronotherapeutics;
Academic Unit:	Faculty of Science and Engineering > Psychology
Item ID:	12133
Identification Number:	https://doi.org/10.1136/postgradmedj-2018-135719
Depositing User:	Dr. Andrew Coogan
Date Deposited:	10 Jan 2020 16:17
Journal or Publication Title:	Postgraduate Medical Journal
Publisher:	BMJ Publishing Group
Refereed:	Yes
URI:	https://pmj.bmj.com
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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