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    Combined fMRI and metabolic voltammetry in vivo: understanding the neurochemical basis of functional imaging signals


    Sibson, Nicola R. and McHugh, S. and Lowry, John P. (2009) Combined fMRI and metabolic voltammetry in vivo: understanding the neurochemical basis of functional imaging signals. Journal of Cerebral Blood Flow & Metabolism, 29 (1_Supp). pp. 613-614. ISSN 0271-678X

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    Abstract

    Objectives:The use of functional magnetic resonance imaging (fMRI) in both basic and clinical neuroscience is rapidly expanding. However, although advance shave been made in correlating fMRI responses with the underlying neuronal activity, the fact remains that this technique does not directly measure neuronal activity but associated haemodynamic (and metabolic)events. Moreover, a constant relationship between neuronal, haemodynamic and metabolic processes across different brain regions is frequently assumed,despite substantial differences in neuronal architecture.Only by fully understanding the relationship between these parameters will we be able to fully utilise functional neuroimaging. Therefore, we must find away of correlating fMRI data, which largely reflects the haemodynamic component,with neural and/or meta-bolic information. Long-term in-vivo electrochemistry(LIVE) enables real-time measurement of brain metabolites.1In this study we have developed methods for simultaneous fMRI and tissue oxygen measurements via LIVE for direct correlation of metabolic and haemodynamic factors...

    Item Type: Article
    Keywords: Brain Imaging; MRI/fMRI;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 12549
    Identification Number: https://doi.org/10.1038/jcbfm.2009.172
    Depositing User: John Lowry
    Date Deposited: 09 Mar 2020 16:56
    Journal or Publication Title: Journal of Cerebral Blood Flow & Metabolism
    Publisher: SAGE Publications
    Refereed: Yes
    URI:

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