Maguire, Rebecca and Drummond, Frances J. and Hanly, Paul and Gavin, Anna and Sharp, Linda
(2019)
Problems sleeping with prostate cancer: exploring possible risk factors for sleep disturbance in a population-based sample of survivors.
Supportive Care in Cancer, 27.
pp. 3365-3373.
ISSN 0941-4355
Abstract
Purpose: This study aimed to investigate the prevalence of sleeping problems in prostate cancer survivors and to explore the role
of predisposing, precipitating and perpetuating factors in this process.
Methods: Using a cross-sectional design, 3348 prostate cancer survivors between 2 and 18 years post diagnosis reported experiences of insomnia using the QLQC30, along with their sociodemographic characteristics, health status and treatment(s)
received. The EQ5D-5L and QLQPR25 assessed survivors’ overall and prostate cancer–specific health-related quality of life.
A hierarchical multiple regression analysis was constructed with three blocks: (1) predisposing (e.g. demographics at diagnosis),
(2) precipitating (e.g. disease extent, treatment) and (3) perpetuating factors (e.g. side effects).
Results: Nineteen percent of survivors reported significant problems sleeping. The final model accounted for 31% of the variance
in insomnia scores (p < .001). In order of magnitude, associates of sleep disturbance were urinary symptoms (β = 0.22; p < .001),
experiencing symptoms of depression/anxiety (β = 0.18; p < .001), hormone treatment–related symptoms (β = 0.12; p = .001),
pain (β = 0.10; p < .001) and bowel symptoms (β = 0.06; p = .005). Having a lower education and more comorbidities at diagnosis also predicted sleep problems.
Conclusion: Results suggest that it is the ongoing adverse effects of prostate cancer and its treatment (e.g. urinary symptoms) that
put survivors most at risk of sleep problems. Strong associations with symptoms of depression/anxiety were also observed.
Findings highlight the need for health care practitioners to treat and manage adverse effects of prostate cancer treatment in order
to mitigate sleep disturbance in survivors.
| Item Type: |
Article
|
| Additional Information: |
This work was funded by the Health Research Board in the
Republic of Ireland, (HRA_HSR/2010/17), Prostate Cancer UK (NI09-
03 and NI-PG13-001), the R&D Office of the Public Health Agency in
Northern Ireland and the National Cancer Control Programme in the RoI.
This research received no specific grant from any funding agency in the
commercial or not-for-profit sectors. The Northern Ireland Cancer
Registry is funded by the Public Health Agency for Northern Ireland
and the National Cancer Registry Ireland by the Department of Health. |
| Keywords: |
Prostate cancer; Insomnia; Adverse side effects; Depression; Anxiety; Pain; |
| Academic Unit: |
Faculty of Science and Engineering > Psychology |
| Item ID: |
13421 |
| Identification Number: |
https://doi.org/10.1007/s00520-018-4633-z |
| Depositing User: |
Rebecca Maguire
|
| Date Deposited: |
07 Oct 2020 15:41 |
| Journal or Publication Title: |
Supportive Care in Cancer |
| Publisher: |
Springer |
| Refereed: |
Yes |
| Funders: |
Health Research Board (HRB), Prostate Cancer UK, Public Health Agency (Northern Ireland), National Cancer Control Programme (ROI) |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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