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    Impact of Adult Attention Deficit Hyperactivity Disorder and Medication Status on Sleep/Wake Behavior and Molecular Circadian Rhythms

    Coogan, Andrew and Schenk, M and Palm, D and Uzoni, A and Grube, J and Tsang, A H and Kolbe, I and McGowan, N M and Wandschneider, R and Colla, M and Oster, H and Thorne, J and Faltraco, Frank (2019) Impact of Adult Attention Deficit Hyperactivity Disorder and Medication Status on Sleep/Wake Behavior and Molecular Circadian Rhythms. Neuropsychopharmacology, 44. pp. 1198-1206. ISSN 0893-133X

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    Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition that has been strongly associated with changes in sleep and circadian rhythms. Circadian rhythms are near 24-h cycles that are primarily generated by an endogenous circadian timekeeping system, encoded at the molecular level by a panel of clock genes. Stimulant and non-stimulant medication used in the management of ADHD has been shown to potentially impact on circadian processes and their behavioral outputs. In the current study, we have analyzed circadian rhythms in daily activity and sleep, and the circadian gene expression in a cohort of healthy controls (N = 22), ADHD participants not using ADHD-medication (N = 17), and participants with ADHD and current use of ADHD medication (N = 17). Rhythms of sleep/wake behavior were assessed via wrist-worn actigraphy, whilst rhythms of circadian gene expression were assessed ex-vivo in primary human-derived dermal fibroblast cultures. Behavioral data indicate that patients with ADHD using ADHD-medication have lower relative amplitudes of diurnal activity rhythms, lower sleep efficiency, more nocturnal activity but not more nocturnal wakenings than both controls and ADHD participants without medication. At the molecular level, there were alterations in the expression of PER2 and CRY1 between ADHD individuals with no medication compared to medicated ADHD patients or controls, whilst CLOCK expression was altered in patients with ADHD and current medication. Analysis of fibroblasts transfected with a BMAL1:luc reporter showed changes in the timing of the peak expression across the three groups. Taken together, these data support the contention that both ADHD and medication status impact on circadian processes.

    Item Type: Article
    Keywords: adult attention deficit hyperactivity disorder; medication; sleep/wake behaviour; molecular circadian rhythms;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 13469
    Identification Number:
    Depositing User: Dr. Andrew Coogan
    Date Deposited: 29 Oct 2020 11:45
    Journal or Publication Title: Neuropsychopharmacology
    Publisher: Springer Nature (American College of Neuropsychopharmacology (ACNP))
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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