Wu, Luling and Gardiner, Jordan E. and Kumawat, Lokesh Kumar and Han, Hai-Hao and Guo, Ruiying and Li, Xin and He, Xiao-Peng and Elmes, Robert B.P. and Sedgwick, Adam C. and Bull, Steven D and James, Tony D.
(2019)
Coumarin-based fluorescent ‘AND’ logic gate
probes for the detection of homocysteine and
a chosen biological analyte.
RSC Advances, 9.
pp. 26425-26428.
ISSN 2046-2069
Abstract
With this research we set out to develop a number of coumarin-based ‘AND’ logic fluorescence probes that
were capable of detecting a chosen analyte in the presence of HCys. Probe JEG-CAB was constructed by
attaching the ONOO� reactive unit, benzyl boronate ester, to a HCys/Cys reactive fluorescent probe, CAH.
Similarly, the core unit CAH was functionalised with the nitroreductase (NTR) reactive p-nitrobenzyl unit to
produce probe JEG-CAN. Both, JEG-CAB and JEG-CAN exhibited a significant fluorescence increase when
exposed to either HCys and ONOO� (JEG-CAB) or HCys and NTR (JEG-CAN) thus demonstrating their
effectiveness to function as AND logic gates for HCys and a chosen analyte.
| Item Type: |
Article
|
| Keywords: |
Coumarin-based fluorescent; logic gate; probes; detection; homocysteine; chosen; biological analyte; |
| Academic Unit: |
Faculty of Science and Engineering > Chemistry |
| Item ID: |
13853 |
| Identification Number: |
https://doi.org/10.1039/C9RA04908H |
| Depositing User: |
Robert Elmes
|
| Date Deposited: |
22 Jan 2021 11:10 |
| Journal or Publication Title: |
RSC Advances |
| Publisher: |
Royal Society of Chemistry |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
Repository Staff Only(login required)
 |
Item control page |
Downloads per month over past year
Origin of downloads
Altmetric
Altmetric