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    Electrochemical detection of glucose at physiological pH using gold nanoparticles deposited on carbon nanotubes


    Branagan, David and Breslin, Carmel B. (2019) Electrochemical detection of glucose at physiological pH using gold nanoparticles deposited on carbon nanotubes. Sensors and Actuators B: Chemical, 282. pp. 490-499. ISSN 0925-4005

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    Abstract

    There is currently considerable interest in the development of non–enzymatic glucose sensors and gold is one of the noble metals that enables the oxidation of glucose. Gold nanoparticles with a mean diameter of 7.5 nm were deposited onto the walls of functionalised carbon nanotubes to give a gold loading of 2.0% by weight. This composite was dispersed and cast onto glassy carbon and carbon screen printed electrodes. These electrodes were then used to detect glucose in a neutral phosphate buffer solution, corresponding to physiological pH. Using constant potential amperometry, a linear calibration curve was obtained with a sensitivity of 2.77 ± 0.14 μA/mM, a limit of detection, LOD, of 4.1 μM and a linear region extending to 25 mM. This sensor showed very good selectivity in the presence of ascorbic acid, galactose and fructose, but interference was observed in the presence of uric acid. This interference was eliminated by applying a Nafion® film to the composite electrodes. Due to a lower diffusion of glucose across the Nafion® barrier, the sensitivity of the Nafion® coated composite was reduced to 0.55 ± 0.03 μA/mM and the LOD was increased to 10.0 μM. However, a linear response between 0.1mM and 25mM was obtained, which covers the normal and elevated levels of glucose in blood. These sensors showed very good stability when stored in air and it was also possible to re–use the sensors.

    Item Type: Article
    Additional Information: Cite as: David Branagan, Carmel B. Breslin, Electrochemical detection of glucose at physiological pH using gold nanoparticles deposited on carbon nanotubes, Sensors and Actuators B: Chemical, Volume 282, 2019, Pages 490-499, ISSN 0925-4005, https://doi.org/10.1016/j.snb.2018.11.089
    Keywords: Carbon nanotubes; Gold nanoparticles; Nanocomposite; Glucose sensor; non–enzymatic; Physiological pH;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 14141
    Identification Number: https://doi.org/10.1016/j.snb.2018.11.089
    Depositing User: Dr. Carmel Breslin
    Date Deposited: 09 Mar 2021 14:24
    Journal or Publication Title: Sensors and Actuators B: Chemical
    Publisher: Elsevier
    Refereed: Yes
    URI:

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