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    The selective electrochemical sensing of dopamine at a polypyrrole film doped with an anionic β−cyclodextrin


    Harley, Claire C. and Annibaldi, Valeria and Yu, Tian and Breslin, Carmel B. (2019) The selective electrochemical sensing of dopamine at a polypyrrole film doped with an anionic β−cyclodextrin. Journal of Electroanalytical Chemistry, 855 (113614). ISSN 1572-6657

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    Abstract

    Pyrrole was electropolymerised in a 0.01 M sulfonated β−cyclodextrin solution to generate an adherent polypyrrole film doped with the anionic sulfonated β−cyclodextrin, PPy−SβCD. This polymeric material was used as an electrochemical sensor for the detection of dopamine (DA), and compared with the sensing abilities of polypyrrole doped with several more common anionic dopants. The sensing performance of the PPy−SβCD film was significantly better, with a linear calibration curve extending to 50 μM, with a sensitivity of 0.90 μA μM−1 cm−2 and a detection limit of 1.0 × 10−6 M. Excellent selectivity was achieved and no interference was observed from a range of interference compounds, including ascorbic acid, uric acid, aspartic acid, acetylcholine, aminobutyric acid, glutamic acid, glycine, histamine, acetaminophenol 5−hydroxytryptamine and 5−hydroxyindole acetic acid. However, interference was seen with the structurally−related epinephrine (Ep) and 3,4−dihydroxyphenylacetic acid (DOPAC), with the oxidation of DA, Ep and DOPAC occurring at similar potentials. The good selectivity in the presence of the other interference species was attributed to an interaction between the cyclodextrin dopant and the protonated DA molecule which was evident when data were fitted to Michaelis−Menten and Lineweaver−Burk kinetics.

    Item Type: Article
    Additional Information: Cite as: Claire C. Harley, Valeria Annibaldi, Tian Yu, Carmel B. Breslin, The selective electrochemical sensing of dopamine at a polypyrrole film doped with an anionic β−cyclodextrin, Journal of Electroanalytical Chemistry, Volume 855, 2019, 113614, ISSN 1572-6657, https://doi.org/10.1016/j.jelechem.2019.113614.
    Keywords: Dopamine sensor; Sulfonated β−cyclodextrin; Ascorbic acid; Uric acid; Selectivity; Sensitivity;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 14145
    Identification Number: https://doi.org/10.1016/j.jelechem.2019.113614
    Depositing User: Dr. Carmel Breslin
    Date Deposited: 09 Mar 2021 15:02
    Journal or Publication Title: Journal of Electroanalytical Chemistry
    Publisher: Elsevier
    Refereed: Yes
    URI:

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