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    The incorporation of drug molecules with poor water solubility into polypyrrole as dopants: Indomethacin and sulindac


    Ryan, Eimear M. and Breslin, Carmel B. (2019) The incorporation of drug molecules with poor water solubility into polypyrrole as dopants: Indomethacin and sulindac. Electrochimica Acta, 296. pp. 848-855. ISSN 0013-4686

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    Abstract

    There is considerable interest in the development of polypyrrole–based drug delivery systems. However, it is not possible to incorporate drugs with limited water solubility into polypyrrole from the usual aqueous–based electropolymerisation solutions. In this study, two drugs with poor solubility in water, sulindac and indomethacin, were incorporated within polypyrrole films as dopants from an ethanol–containing electropolymerisation solution to give PPyIndo and PPySul. An organic perchlorate salt was added to the electropolymerisation solution and the resulting perchlorate dopant anions were released initially on reducing the PPyIndo and PPySul at −0.70 V vs SCE. The drug molecules were then re–doped in the absence of the perchlorate salt. On reduction of the polymer films the sulindac and indomethacin were released into an aqueous saline solution, giving approximately 0.12 mg cm−2 of sulindac and 0.29 mg cm−2 of indomethacin over a 60 min release period. The greater amounts of indomethacin released from PPyIndo were explained in terms of higher doping levels. The doping levels of indomethacin and sulindac were estimated at 0.28 and 0.10, respectively, using electrochemical quartz crystal microbalance measurements.

    Item Type: Article
    Additional Information: Cite as: Eimear M. Ryan, Carmel B. Breslin, The incorporation of drug molecules with poor water solubility into polypyrrole as dopants: Indomethacin and sulindac, Electrochimica Acta, Volume 296, 2019, Pages 848-855, ISSN 0013-4686, https://doi.org/10.1016/j.electacta.2018.11.107.
    Keywords: Polypyrrole; Poorly soluble drugs; Sulindac; Indomethacin; Ethanol;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 14147
    Identification Number: https://doi.org/10.1016/j.electacta.2018.11.107
    Depositing User: Dr. Carmel Breslin
    Date Deposited: 09 Mar 2021 15:11
    Journal or Publication Title: Electrochimica Acta
    Publisher: Elsevier B.V.
    Refereed: Yes
    URI:

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