Wyse, C.A. and O'Malley, Grace and Coogan, Andrew and McConkey, Sam and Smith, Daniel J. (2021) Seasonal and Daytime Variation in Multiple Immune Parameters in Humans: Evidence from 329,261 Participants of the UK Biobank Cohort. iScience. ISSN 2589-0042

Preview

Download (2MB) | Preview

Abstract

Seasonal disease outbreaks are perennial features of human infectious disease but the factors generating these patterns are unclear. Here we investigate seasonal and daytime variability in multiple immune parameters in 329,261 participants in UK Biobank, and test for associations with a wide range of environmental and lifestyle factors, including changes in day length, outdoor temperature and vitamin D at the time the blood sample was collected. Seasonal patterns were evident in lymphocyte and neutrophil counts, and CRP, but not monocytes, and these were independent of lifestyle, demographic and environmental factors. All the immune parameters assessed demonstrated significant daytime variation that was independent of confounding factors. At a population level, human immune parameters vary across season and across time of day, independent of multiple confounding factors. Both season and time of day are fundamental dimensions of immune function that should be considered in all studies of immuno-prophylaxis and disease transmission.

Item Type:	Article
Keywords:	Seasonal and Daytime Variation; Multiple Immune Parameters; Humans; Evidence; UK Biobank Cohort;
Academic Unit:	Faculty of Science and Engineering > Psychology
Item ID:	14165
Identification Number:	https://doi.org/10.1016/j.isci.2021.102255
Depositing User:	Dr. Andrew Coogan
Date Deposited:	11 Mar 2021 10:12
Journal or Publication Title:	iScience
Publisher:	Cell Press
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads