Ahmed, Muhib and Rooney, A. Denise and McCann, Malachy and Casey, Jamie and O'Shea, Katie and Twanley, Brendan (2019) Tuning the reaction pathways of phenanthroline-Schiff bases: routes to novel phenanthroline ligands. Dalton Transactions, 48. pp. 15283-15289. ISSN 1477-9226

Preview

Download (545kB) | Preview

Abstract

Pyrido-phenanthrolin-7-one compounds are structural analogues of the cytotoxic alkaloid, ascididemin, and would be expected to have interesting biological activities. Synthetic strategies are reported for a novel simple route to form this class of ligand. 1,10-Phenanthrolin-5,6-dione reacts with L-phenylalanine alkyl esters and their para-substituted analogues to form both a phenanthroline–oxazine and a pyrido-phenanthrolin- 7-one product. The nature of the major product is dependent on the electronic properties of the para substituent. Successful metal coordination to the pyrido-phenanthrolin-7-one ligand is also presented.

Item Type:	Article
Additional Information:	Cite as: Dalton Trans., 2019,48, 15283-15289
Keywords:	Tuning; reaction; pathways; phenanthroline- Schiff bases; routes; novel; phenanthroline ligands;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	14519
Identification Number:	https://doi.org/10.1039/C9DT03084K
Depositing User:	Dr. Denise Rooney
Date Deposited:	09 Jun 2021 13:59
Journal or Publication Title:	Dalton Transactions
Publisher:	Royal Society of Chemistry
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads