Tonoyana, Lilit and Montagner, Diego and Friel, Ruairi and O'Flaherty, Vincent (2020) Antimicrobials offered from nature: Peroxidase-catalyzed systems and their mimics. Biochemical Pharmacology, 182 (114281). ISSN 0006-2952,

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Abstract

The control of antimicrobial resistance requires the development of novel antimicrobial alternatives and naturally occurring peroxidase-catalyzed systems may be of great value in this era of emerging antimicrobial resistance. In the peroxidase system, a peroxidase enzyme catalyzes the oxidation of a halide/pseudohalide, at the expense of hydrogen peroxide, to generate reactive products with broad antimicrobial properties. The appropriate use of peroxidase systems needs a better understanding of the identities and properties of the generated antimicrobial oxidants, specific targets in bacterial cells, their mode of action and the factors favoring or limiting their activity. Here, the ABCs (antibacterial activity, bacterial “backtalk” and cytotoxicity) of these systems and their mimics are discussed. Particular attention is paid to the concomitant use of thiocyanate and iodide dual substrates in peroxidase/peroxidase-free systems with implications on their antimicrobial activity. This review also provides a summary of actual applications of peroxidase systems as bio-preservatives in oral healthcare, milk industry, food/feed specialties and related products, mastitis and wound treatment; lastly, this review points to opportunities for further research and potential applications.

Item Type:	Article
Additional Information:	© 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Cite as: Lilit Tonoyan, Diego Montagner, Ruairi Friel, Vincent O'Flaherty, Antimicrobials offered from nature: Peroxidase-catalyzed systems and their mimics, Biochemical Pharmacology, Volume 182, 2020, 114281, ISSN 0006-2952, https://doi.org/10.1016/j.bcp.2020.114281. (https://www.sciencedirect.com/science/article/pii/S0006295220305177)
Keywords:	Antimicrobial agents; Peroxidase-catalyzed systems; Mechanism of action; Antimicrobial resistance; Cytotoxicity;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	14742
Identification Number:	https://doi.org/10.1016/j.bcp.2020.114281
Depositing User:	Diego Montagner
Date Deposited:	02 Sep 2021 16:47
Journal or Publication Title:	Biochemical Pharmacology
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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