Sukanya, R. and Balamurugan, K. and Chen, S.-M. and Rajakumaran, R. and Muthupandi, K. and Shim, J.-J. and Breslin, Carmel B. (2021) Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole. Materials, 14 (6700). ISSN 1996-1944

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Abstract

In this study, we synthesized heterostructured zinc stannate/tin oxide microparticles (ZTO/TO MPs) by a simple coprecipitation method and used them as an effective electrode material for the electrochemical detection of the antibacterial drug secnidazole (SCZ). The as-prepared ZTO/TO MPs were characterized by XRD, Raman, FE-SEM, HR-TEM, EDX, and XPS analyses. The physiochemical studies clearly proved that the fabricated ZTO/TO MPs were formed in a heterostructure phase without other impurities. A glassy carbon electrode modified with the synthesized ZTO/TO MPs showed an excellent and improved electrocatalytic activity in the electrochemical reduction of SCZ. Using differential pulse voltammetry (DPV), an impressive linear calibration range, extending from 0.01 to 193 μM, was observed, coupled with a detection limit of 0.0054 μM and a sensitivity of 0.055 μA/μM. In addition, the ZTO/TO MPs/GCE showed very good selectivity for the detection of SCZ in the presence of a number of biological, inorganic, and structurally related compounds. Finally, the ZTO/TO MPs/GCE was investigated for the analysis of SCZ in human blood serum samples. A very good recovery was obtained when spiking the blood serum with SCZ, highlighting the good applicability of the ZTO/TO MPs/GCE for the electrochemical analysis of SCZ in complex biological samples.

Item Type:	Article
Additional Information:	Funding: This research was funded by the Ministry of Science and Technology (MOST 110-2113-M-027-003), Taiwan, and by the Science Foundation Ireland (20/FFP-P/8793). Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Cite as: Sukanya, R.; Balamurugan, K.; Chen, S.-M.; Rajakumaran, R.; Muthupandi, K.; Shim, J.-J.; Breslin, C.B. Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole. Materials 2021, 14, 6700. https://doi.org/10.3390/ma14216700
Keywords:	ternary metal oxides; heterostructure; electrochemical sensor; secnidazole; Zn2SnO4/SnO2 MPs;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	15090
Identification Number:	https://doi.org/10.3390/ma14216700
Depositing User:	Dr. Carmel Breslin
Date Deposited:	06 Dec 2021 16:10
Journal or Publication Title:	Materials
Publisher:	MDPI AG
Refereed:	Yes
Funders:	Ministry of Science and Technology, Taiwan, Science Foundation Ireland (SFI)
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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