Healy, Bronach and Yu, Tian and Alves, Daniele C. da Silva and Okeke, Cynthia and Breslin, Carmel B. (2021) Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors. Materials, 14 (1668). ISSN 1996-1944

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Abstract

Supramolecular chemistry, although focused mainly on noncovalent intermolecular and intramolecular interactions, which are considerably weaker than covalent interactions, can be employed to fabricate sensors with a remarkable affinity for a target analyte. In this review the development of cyclodextrin-based electrochemical sensors is described and discussed. Following a short introduction to the general properties of cyclodextrins and their ability to form inclusion complexes, the cyclodextrin-based sensors are introduced. This includes the combination of cyclodextrins with reduced graphene oxide, carbon nanotubes, conducting polymers, enzymes and aptamers, and electropolymerized cyclodextrin films. The applications of these materials as chiral recognition agents and biosensors and in the electrochemical detection of environmental contaminants, biomolecules and amino acids, drugs and flavonoids are reviewed and compared. Based on the papers reviewed, it is clear that cyclodextrins are promising molecular recognition agents in the creation of electrochemical sensors, chiral sensors, and biosensors. Moreover, they have been combined with a host of materials to enhance the detection of the target analytes. Nevertheless, challenges remain, including the development of more robust methods for the integration of cyclodextrins into the sensing unit.

Item Type:	Article
Additional Information:	Funding: This research was funded by Irish Research Council, award number GOIPG/2020/657 and Maynooth University. Copyright: : © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Cite as: Healy, B.; Yu, T.; C. da Silva Alves, D.; Okeke, C.; Breslin, C.B. Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors. Materials 2021, 14, 1668. https://doi.org/10.3390/ma14071668
Keywords:	cyclodextrins; inclusion complex; electrochemical sensors; biosensors; chiral recognition;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	15094
Identification Number:	https://doi.org/10.3390/ma14071668
Depositing User:	Dr. Carmel Breslin
Date Deposited:	06 Dec 2021 16:47
Journal or Publication Title:	Materials
Publisher:	MDPI AG
Refereed:	Yes
Funders:	Irish Research Council (IRC), Maynooth University
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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