Gallagher, Louise, Smith, Alanna, Kavanagh, Kevin, Devereux, Michael, Colleran, John, Breslin, Carmel B., Richards, K.G., McCann, Malachy and Rooney, A. Denise (2021) Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions. Chemistry, 3 (2). pp. 672-686. ISSN 2624-8549
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Abstract
Calcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trimethoxysilyl)propyl)-octadecyldimethylammonium chloride (QA), (CaALG/QA), were prepared. Bovine serum albumin (BSA) was condensed with glutaraldehyde (GLA) to form a BSA/GLA hydrogel. The corresponding Ag+-containing gels of all of the above hydrogels were also formed, and slow leaching of the biocidal transition metal ion from the gels bestowed broad spectrum antimicrobial activity. In the absence of added Ag+, CaALG/QA was the only material to deliver marginal to moderate antibacterial and antifungal effects. The Ag+ impregnated hydrogel systems have the potential to maintain the antimicrobial properties of silver, minimising the risk of toxicity, and act as reservoirs to afford ongoing sterility.
Item Type: | Article |
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Additional Information: | Funding: This research was funded by PRTLI strand IV, Monaghan County Council and the Irish Department of Agriculture, Food and the Marine (DAFM) (Research Stimulus Fund Programme— RSF 07545). Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Cite as: Gallagher, L.; Smith, A.; Kavanagh, K.; Devereux, M.; Colleran, J.; Breslin, C.; Richards, K.G.; McCann, M.; Rooney, A.D. Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions. Chemistry 2021, 3, 672-686. https://doi.org/10.3390/chemistry3020047 |
Keywords: | hydrogel; alginate; BSA; glutaraldehyde; silver; antimicrobial; |
Academic Unit: | Faculty of Science and Engineering > Chemistry |
Item ID: | 15098 |
Identification Number: | 10.3390/chemistry3020047 |
Depositing User: | Dr. Carmel Breslin |
Date Deposited: | 07 Dec 2021 15:12 |
Journal or Publication Title: | Chemistry |
Publisher: | MDPI AG |
Refereed: | Yes |
Funders: | PRTLI strand IV, Monaghan County Council, Department of Agriculture, Food and the Marine (DAFM) |
Related URLs: | |
URI: | https://mural.maynoothuniversity.ie/id/eprint/15098 |
Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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