Gallagher, Louise and Smith, Alanna and Kavanagh, Kevin and Devereux, Michael and Colleran, John and Breslin, Carmel B. and Richards, K.G. and McCann, Malachy and Rooney, A. Denise (2021) Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions. Chemistry, 3 (2). pp. 672-686. ISSN 2624-8549

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Abstract

Calcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trimethoxysilyl)propyl)-octadecyldimethylammonium chloride (QA), (CaALG/QA), were prepared. Bovine serum albumin (BSA) was condensed with glutaraldehyde (GLA) to form a BSA/GLA hydrogel. The corresponding Ag+-containing gels of all of the above hydrogels were also formed, and slow leaching of the biocidal transition metal ion from the gels bestowed broad spectrum antimicrobial activity. In the absence of added Ag+, CaALG/QA was the only material to deliver marginal to moderate antibacterial and antifungal effects. The Ag+ impregnated hydrogel systems have the potential to maintain the antimicrobial properties of silver, minimising the risk of toxicity, and act as reservoirs to afford ongoing sterility.

Item Type:	Article
Additional Information:	Funding: This research was funded by PRTLI strand IV, Monaghan County Council and the Irish Department of Agriculture, Food and the Marine (DAFM) (Research Stimulus Fund Programme— RSF 07545). Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Cite as: Gallagher, L.; Smith, A.; Kavanagh, K.; Devereux, M.; Colleran, J.; Breslin, C.; Richards, K.G.; McCann, M.; Rooney, A.D. Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions. Chemistry 2021, 3, 672-686. https://doi.org/10.3390/chemistry3020047
Keywords:	hydrogel; alginate; BSA; glutaraldehyde; silver; antimicrobial;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	15098
Identification Number:	https://doi.org/10.3390/chemistry3020047
Depositing User:	Dr. Carmel Breslin
Date Deposited:	07 Dec 2021 15:12
Journal or Publication Title:	Chemistry
Publisher:	MDPI AG
Refereed:	Yes
Funders:	PRTLI strand IV, Monaghan County Council, Department of Agriculture, Food and the Marine (DAFM)
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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