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    Disposable Printed Lateral Flow Electrochemical Immunosensors for Human Cardiac Troponin T

    Dempsey, Eithne and Rathod, Dhanraj (2018) Disposable Printed Lateral Flow Electrochemical Immunosensors for Human Cardiac Troponin T. IEEE Sensors Journal, 18 (5). pp. 1828-1834. ISSN 1530-437X

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    Here we report an electrochemical ELISA approach for cardiac Troponin T (cTnT) determination based on a lateral flow membrane with underlying screen printed electrodes ( $<100~\Omega $ /cm2). The thick film transducer was modified with the anti-cardiac Troponin T antibody via physisorption and the electrochemical performance of the immunosensor was evaluated using cyclic voltammetry. The capture antibody coated immunoelectrode employed for electrochemical determination of Troponin T antigen used a sandwich assay format with horseradish peroxidase conjugated signaling antibodies held in the track of a lateral flow sensor strip. A simple two step procedure realized signal acquisition within <20 min (total assay time). The lateral flow electrochemical immunosensor response resulted in a calibration curve with linear response (0–700 ng/ml cTnT) with limit of detection of 0.15 ng/ml.

    Item Type: Article
    Keywords: Immunosensor; Troponin T; lateral flow immunoassay;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 16102
    Identification Number:
    Depositing User: Eithne Dempsey
    Date Deposited: 14 Jun 2022 15:22
    Journal or Publication Title: IEEE Sensors Journal
    Publisher: Institute of Electrical and Electronics Engineers
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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