Fredj, Zina and Ben Ali, Mounir and Abbas, Mohammed Nooredeen and Dempsey, Eithne (2020) Simultaneous determination of ascorbic acid, uric acid and dopamine using silver nanoparticles and copper monoamino-phthalocyanine functionalised acrylate polymer. Analytical Methods, 12 (31). pp. 3883-3891. ISSN 1759-9660

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Abstract

A silver nanoparticle and copper monoamino-phthalocyanine-acrylate (Cu-MAPA) polymer modified glassy carbon electrode was developed for the simultaneous detection of dopamine (DOP), ascorbic acid (AA) and uric acid (UA) using voltammetric techniques. Silver nanoparticles (AgNPs) were synthesised according to the citrate reduction method. Following synthesis and characterisation the copper phthalocyanine polymer was co-deposited with AgNPs realising a surface with enhanced electron transfer which lowered the overpotential required for analyte electro-oxidation. Differential pulse voltammetry (DPV) was employed for the simultaneous determination of dopamine (DOP), ascorbic acid (AA) and uric acid (UA) at AgNP/Cu-MAPA modified surfaces at <μM ranges. The peak potential separations for DOP-AA and DOP-UA were ca. 181 mV and 168 mV respectively. The chemical sensor was also capable of individual quantitation of DOP, UA and AA with detection limits of 0.7, 2.5 and 5.0 nM respectively. Overall, the approach realised a simple and effective electrode modifier for the selective discrimination and quantitation of DOP in the presence of physiological levels of AA and UA.

Item Type:	Article
Keywords:	Simultaneous determination; ascorbic acid; uric acid; dopamine; silver nanoparticles; copper monoamino-phthalocyanine; functionalised acrylate; polymer;
Academic Unit:	Faculty of Science and Engineering > Chemistry Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	16159
Identification Number:	https://doi.org/10.1039/D0AY01183E
Depositing User:	Eithne Dempsey
Date Deposited:	21 Jun 2022 09:49
Journal or Publication Title:	Analytical Methods
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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