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    mdrl Ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines


    Daly, Carmel and Coyle, Seamus and O'Dea, Shirley and O'Driscoll, Lorraine and Daly, Noel and Scanlon, Kevin and Clynes, Martin (1996) mdrl Ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines. Cytotechnology, 19. pp. 199-205. ISSN 0920-9069

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    Abstract

    An mdrl hammerhead was introduced into two adriamycin-selected multi-drug resistant human lung cell lines both of which over-express p-glycoprotein. Expression of the ribozyme resulted in a decrease in mdrl mRNA expression and an increase in drug sensitivity in both cell lines. This would suggest that the use of specific ribozymes may represent an effective and specific approach in order to restore cellular sensitivity towards anti-cancer drugs.

    Item Type: Article
    Keywords: human lung lines; drug resistance; mdrl; ribozyme;
    Academic Unit: Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 16290
    Depositing User: Dr. Shirley O'Dea
    Date Deposited: 12 Jul 2022 12:39
    Journal or Publication Title: Cytotechnology
    Publisher: Springer Verlag
    Refereed: Yes
    URI:
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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