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    Chronobiology of Parkinson's disease: Past, present and future

    Asadpoordezaki, Ziba and Coogan, Andrew and Henley, Beverley (2022) Chronobiology of Parkinson's disease: Past, present and future. European Journal of Neuroscience. ISSN 0953-816X

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    Parkinson’s disease is a neurodegenerative disorder predominately affecting midbrain dopaminergic neurons that results in a broad range of motor and non-motor symptoms. Sleep complaints are among the most common non- motor symptoms, even in the prodromal period. Sleep alterations in Parkin- son’s disease patients may be associated with dysregulation of circadian rhythms, intrinsic 24-h cycles that control essential physiological functions, or with side effects from levodopa medication and physical and mental health challenges. The impact of circadian dysregulation on sleep disturbances in Parkinson’s disease is not fully understood; as such, we review the systems, cellular and molecular mechanisms that may underlie circadian perturbations in Parkinson’s disease. We also discuss the potential benefits of chronobiology- based personalized medicine in the management of Parkinson’s disease both in terms of behavioural and pharmacological interventions. We propose that a fuller understanding of circadian clock function may shed important new light on the aetiology and symptomatology of the disease and may allow for improvements in the quality of life for the millions of people with Parkinson’s disease.

    Item Type: Article
    Keywords: chronotherapy; circadian clocks; circadian rhythm; neurodegenerative diseases; Parkinson’s disease; sleep–wake disorders;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 16797
    Identification Number:
    Depositing User: Beverley Henley
    Date Deposited: 05 Jan 2023 12:10
    Journal or Publication Title: European Journal of Neuroscience
    Publisher: Blackwell Publishing Ltd
    Refereed: No
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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