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    Electrocatalytic Studies of Coral-Shaped Samarium Stannate Nanoparticles for Selective Detection of Azathioprine in Biological Samples


    Rajakumaran, Ramachandran, Balamurugan, Karuppaiah, Chen, Shen-Ming, Sukanya, Ramaraj and Breslin, Carmel B. (2021) Electrocatalytic Studies of Coral-Shaped Samarium Stannate Nanoparticles for Selective Detection of Azathioprine in Biological Samples. ACS Applied Nano Materials, 4 (12). pp. 13048-13059. ISSN 2574-0970

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    Abstract

    An electrochemical sensor was developed based on the pyrochlore-type binary metal oxide samarium stannate nanoparticles (Sm2Sn2O7 NPs). The Sm2Sn2O7 NPs were prepared using the co-precipitation technique, and they were subjected to physiochemical characterizations such as X-ray diffraction (XRD), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). The morphological and elemental information was interpreted by field-emission scanning electron microscopy (FESEM) and high-resolution transmission electron microscopy (HRTEM) analysis. The electrocatalytic sensing of the pharmaceutical drug azathioprine (AZN) was exhibited using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) over the Sm2Sn2O7/GCE (GCE - glassy carbon electrode). The Sm2Sn2O7/GCE had high electrocatalytic behavior for AZN determination with a limit of detection of 4 nM and superior sensitivity of 0.27 μA μM–1 cm–2, and it has a linear range from 0.01 to 948 μM. Furthermore, the Sm2Sn2O7/GCE exhibited excellent selectivity, long-term storage stability, good repeatability, and reproducibility for AZN detection. Additionally, the Sm2Sn2O7/GCE sensor possessed considerable importance for the sensing of AZN in biological fluids for practical applications. We believe that this pyrochlore-based Sm2Sn2O7 NP electrocatalyst can act as a prospective electrode material for the electrochemical determination of AZN in clinical biological applications.
    Item Type: Article
    Additional Information: Cite as: Rajakumaran, R., Balamurugan, K., Chen, S., Sukanya, R. & Breslin, C.B. 2021, "Electrocatalytic Studies of Coral-Shaped Samarium Stannate Nanoparticles for Selective Detection of Azathioprine in Biological Samples", ACS applied nano materials, vol. 4, no. 12, pp. 13048-13059.
    Keywords: pyrochlore oxide; samarium stannate nanoparticles; azathioprine detection; electrochemical sensor biological samples;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17372
    Identification Number: 10.1021/acsanm.1c02591
    Depositing User: Dr. Carmel Breslin
    Date Deposited: 29 Jun 2023 12:33
    Journal or Publication Title: ACS Applied Nano Materials
    Publisher: ACS Publications
    Refereed: Yes
    Related URLs:
    URI: https://mural.maynoothuniversity.ie/id/eprint/17372
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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