Calatrava‐Pérez, Elena and Marchetti, Luke A. and McManus, Gavin J. and Lynch, Dylan M. and Elmes, Robert B. P. and Williams, D. Clive and Gunnlaugsson, Thorfinnur and Scanlan, Eoin M. (2022) Real‐Time Multi‐Photon Tracking and Bioimaging of Glycosylated Theranostic Prodrugs upon Specific Enzyme Triggered Release. Chemistry – A European Journal, 28 (3). ISSN 0947-6539

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Abstract

Real-timetracking of pro drug up take, delivery and activation in vivore presents a major challenge for prodrug development. Here in, we demonstrate the use of novel glycosylated theranostics of the cancer pharmacophore Amonafide in highly-selective, enzymatic triggered release. We show that the use of endogenous enzymes for activated release of the therapeutic component can be observed, in real time, and monitored using one and two-photon bioimag-ing, offering unique insight into the prodrug pharmaco kinetic profile. Furthermore, we demonstrate that the potent cytotoxicity of Amonafide is preserved using this targeted approach.

Item Type:	Article
Additional Information:	Cite as: E. Calatrava-Pérez, L. A. Marchetti, G. J. McManus, D. M. Lynch, R. B. P. Elmes, D. C. Williams, T. Gunnlaugsson, E. M. Scanlan, Chem. Eur. J. 2022, 28, e202103858
Keywords:	Prodrug; Amonafide; endogenous enzymes
Academic Unit:	Faculty of Science and Engineering > Chemistry Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17385
Identification Number:	https://doi.org/10.1002/chem.202103858
Depositing User:	Robert Elmes
Date Deposited:	06 Jul 2023 14:04
Journal or Publication Title:	Chemistry – A European Journal
Publisher:	Wiley
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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