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    G-protein-coupled receptors as therapeutic targets for glioblastoma

    Byrne, Kate F. and Pal, Ajay and Curtin, James F. and Stephens, John C. and Kinsella, Gemma K. (2021) G-protein-coupled receptors as therapeutic targets for glioblastoma. Drugs Discovery Today, 26 (12). pp. 2858-2870. ISSN 1359-6446

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    Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumour in adults. Treatments include surgical resection, radiotherapy, and chemotherapy. Despite this, the prognosis remains poor, with an impacted quality of life during treatment coupled with brain tumour recurrence; thus, new treatments are desperately needed. In this review, we focus on recent advances in G-protein-coupled receptor (GPCR) targets. To date, the most promising targets are the chemokine, cannabinoid, and dopamine receptors, but future work should further examine the melanocortin receptor-4 (MC4R), adhesion, lysophosphatidic acid (LPA) and smoothened (Smo) receptors to initiate new drug-screening strategies and targeted delivery of safe and effective GBM therapies.

    Item Type: Article
    Additional Information: Cite as: Byrne, K.F., Pal, A., Curtin, J.F., Stephens, J.C. & Kinsella, G.K. 2021, "G-protein-coupled receptors as therapeutic targets for glioblastoma", Drug discovery today, vol. 26, no. 12, pp. 2858-2870.
    Keywords: G-protein-coupled receptors; (GPCRs); Glioblastoma multiforme (GBM);
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17447
    Identification Number:
    Depositing User: Dr John Stephens
    Date Deposited: 17 Aug 2023 14:43
    Journal or Publication Title: Drugs Discovery Today
    Publisher: Elsevier
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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