Geraghty, Conor and Wynne, Conor and Elmes, Robert B.P. (2021) 1,8-Naphthalimide based fluorescent sensors for enzymes. Coordination Chemistry Reviews, 437. p. 213713. ISSN 0010-8545

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Abstract

Fluorescent probes have long been valuable tools in the study of biological systems. With the ever-expanding range of known enzymatic biomarkers for disease, it has never been more important to develop synthetically facile, sensitive, selective, and robust methods for the detection of these analytes. The 1,8-naphthalimide fluorophore presents an ideal scaffold on which to design a range of fluorescent probes for an unknowable diversity of biomarkers. With tuneable photophysical properties, synthetic versatility, photostability and a large Stokes shift, the 1,8-naphthalimide has, and continues to be, exploited for the detection of a wide range of enzymatic conversions. This review will outline the recent progress towards the design and synthesis of 1,8-naphthalimide fluorophores for the detection of selected enzymatic conversions.

Item Type:	Article
Additional Information:	Cite as: Conor Geraghty, Conor Wynne, Robert B.P. Elmes, 1,8-Naphthalimide based fluorescent sensors for enzymes, Coordination Chemistry Reviews, Volume 437, 2021, 213713, ISSN 0010-8545, https://doi.org/10.1016/j.ccr.2020.213713
Keywords:	1,8-Naphthalimide;Enzyme activation; Fluorescent sensors; Fluorescent probes; Biomarker detection; Cellular imaging; Diagnostics;
Academic Unit:	Faculty of Science and Engineering > Chemistry Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17884
Identification Number:	https://doi.org/10.1016/j.ccr.2020.213713
Depositing User:	Robert Elmes
Date Deposited:	23 Nov 2023 15:52
Journal or Publication Title:	Coordination Chemistry Reviews
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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