Murphy, Peter R and Wilming, Niklas and Hernandez-Bocanegra, Diana C and Ortega, Genis Prat and Donner, Tobias H (2020) Adaptive Circuit Dynamics Across Human Cortex During Evidence Accumulation in Changing Environments. Cold Spring Harbor Laboratory Press. ISSN bioRxiv

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Abstract

Abstract Many decisions under uncertainty entail the temporal accumulation of evidence that informs about the state of the environment. When environments are subject to hidden changes in their state, maximizing accuracy and reward requires non-linear accumulation of the evidence. How this adaptive, non-linear computation is realized in the brain is unknown. We analyzed human behavior and cortical population activity (measured with magnetoencephalography) recorded during visual evidence accumulation in a changing environment. Behavior and decision-related activity in cortical regions involved in action planning exhibited hallmarks of adaptive evidence accumulation, which could also be implemented by a recurrent cortical microcircuit. Decision dynamics in action-encoding parietal and frontal regions were mirrored in a frequency-specific modulation of the state of visual cortex that depended on pupil-linked arousal and the expected probability of change. These findings link normative decision computations to recurrent cortical circuit dynamics and highlight the adaptive nature of decision-related feedback to sensory cortex. Competing Interest Statement The authors have declared no competing interest. Footnotes * Major revisions to all sections of paper. Three new main text figures (Figures 4, 5, 7) and four new supplementary figures (Supplementary Figures 3, 7, 8, 9). Data from two new experiments.

Item Type:	Article
Keywords:	Arousal; Brain stem; Cortex; Cortex (motor); Cortex (somatosensory; Decision making; Magnetoencephalography;
Academic Unit:	Faculty of Science and Engineering > Psychology
Item ID:	18295
Identification Number:	https://doi.org/10.1101/2020.01.29.924795
Depositing User:	Dr Peter Murphy
Date Deposited:	21 Mar 2024 11:51
Journal or Publication Title:	Cold Spring Harbor Laboratory Press
Publisher:	Proquest
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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