Balamurugan, Karuppaiah and Karthik, Raj and Chen, Shen-Ming and Sukanya, Ramaraj and Thasma Subramanian, Bhuvaneswari and Biju, Valsala Madhavan Nair and Shim, Jae-Jin and Breslin, Carmel B. (2022) Heterostructures of mixed metal oxides (ZnMnO3/ZnO) synthesized by a wet-chemical approach and their application for the electrochemical detection of the drug chlorpromazine. Composites Part B: Engineering, 236 (109822). pp. 1-12. ISSN 13598368

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Abstract

Materials development using heterostructures is generally considered an efficient method for developing electrocatalysts. However, it still faces many challenges, such as instability and accurate phase mixing ratio of metals. On the other hand, the excessive consumption of drugs such as chlorpromazine (CPMZ) leads to several serious human diseases. Therefore, the accurate detection and determination of CPMZ is essential. In this view, a highly efficient electrochemical sensor based on a heterostructure of ZnMnO3/ZnO NPs/GCE was fabricated to detect the psychotic drug CPMZ. The heterostructure of cubic ZnMnO3 (ZMO) and hexagonal zinc oxide nanoparticles (ZMO/ZnO NPs) was synthesized by a simple co-precipitation method followed by thermal calcination. The as-prepared material crystallinity and average crystal size (26 nm) were analyzed by p-XRD. The morphology of the ZMO/ZnO NPs was analyzed by SEM and HR-TEM, which revealed the formation of non-uniform spherical and hexagonal nanoparticles with a size of ∼10-30 nm. FT-IR and XPS were used to investigate the functional groups and oxidation states of the ZMO/ZnO NPs. The electrochemical properties of the ZMO/ZnO NPs/GCE were analyzed by EIS, CV, and DPV methods. ZMO/ZnO/GCE has improved electrochemical activity for detecting CPMZ. In addition, the ZMO/ZnO/GCE electrochemical probe has two linear ranges (0.05–125.55 μM and 185.55–1625 μM) and good sensitivity (0.760 μA μM−1 cm−2) with a low detection limit of 0.019 μM. Analysis of real samples was performed in human blood serum and urine, and the recoveries of CPMZ were 96–100% and 98–100%, respectively.

Item Type:	Article
Keywords:	Heterostructure; ZnMnO3/ZnO NPs; Electrochemical sensor; Psychotic drug; Chlorpromazine sensor;
Academic Unit:	Faculty of Science and Engineering > Chemistry Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	18511
Identification Number:	https://doi.org/10.1016/j.compositesb.2022.109822
Depositing User:	Dr. Carmel Breslin
Date Deposited:	14 May 2024 13:56
Journal or Publication Title:	Composites Part B: Engineering
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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