Karthik, Raj and Balamurugan, Karuppaiah and Chen, Shen-Ming and Sukanya, Ramaraj and R. Chavan, Prajakta and Nguyen, Van Quang and Shim, Jae-Jin and Breslin, Carmel B. (2022) Investigation of the electrocatalytic activity of bismuth-substituted pyrochlore Y2Sn2O7 for the voltammetry determination of the antipsychotic drug. Materials Today Chemistry, 26 (101117). pp. 1-14. ISSN 2468 5194

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Abstract

Pyrochlore oxides are considered active candidates for various electrochemical applications due to their cationic charges and anionic deficiency. At the same time, the cationic substitution of pyrochlore is a crucial parameter to improve the catalytic activity of electrode materials. Against this background, this article aims to synthesize bismuth-substituted defective pyrochlore-yttrium tin oxide nanoparticles (Bi0.6Y1.4Sn2O7; BYSO NPs) and construct an electrochemical sensor for the antipsychotic chlorpromazine (CHPMZ). The catalyst was prepared by co-precipitation technique followed by thermal treatment. The analytical methods, such as p-XRD, FT-IR, TGA, and XPS, confirmed the successful substitution of Y3+ by Bi3+. The morphology of the as-prepared catalysts was analyzed by the FE-SEM and TEM techniques, which shows that the size of nanoparticles is ⁓20–30 nm. From the CV results, the cationic substitution enhances the electrocatalytic oxidation of CHPMZ due to the intrinsic activity enhancement by the substitution with a large size cation and the anionic deficiency of the pyrochlore structure. Moreover, the heterogeneous rate constant of CHPMZ on BYSO/SPCE was calculated to be 4.49 × 10−3 cm/s, indicating that the oxidation of CHPMZ on BYSO/SPCE is quasi-reversible. The electrode modified with BYSO NPs showed wider linear ranges (0.01–58.41 μM, 78.41–1158 μM), high sensitivity (1.03 μA/μM/cm2) with a low detection limit of 3 nM. The modified electrodes showed good selectivity, repeatability, and excellent stability for the detection of CHPMZ. Moreover, the constructed sensor showed promising results in practical analysis with good recovery in human blood serum and urine samples.

Item Type:	Article
Keywords:	Pyrochlore oxide; Cation (Bi3+) substitution; Yttrium tin oxide; Chlorpromazine sensor; Real sample analysis;
Academic Unit:	Faculty of Science and Engineering > Chemistry Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	18559
Identification Number:	https://doi.org/10.1016/j.mtchem.2022.101117
Depositing User:	Dr. Carmel Breslin
Date Deposited:	21 May 2024 14:24
Journal or Publication Title:	Materials Today Chemistry
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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