McCann, Malachy and Coyle, Barry and Kavanagh, Kevin and McKee, Vickie and Kayal, Nijhuma and Egan, Denise and Deegan, Carol Deegan and Finn, Gregory J. and Devereux, Michael (2004) Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2 ¼salicylic acid). Journal of Inorganic Biochemistry, 98 (8). pp. 1361-1366. ISSN 0162-0134

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Abstract

[Ag2(NH3)2(salH)2] (salH2 ¼salicylic acid) was synthesised from salicylic acid and Ag2O in concentrated aqueous NH3 and the dimeric Ag(I) complex was characterised using X-ray crystallography. The complex is centrosymmetric with each metal coordinated to a salicylate carboxylate oxygen and to an ammonia nitrogen atom in an almost linear fashion. The two [Ag(NH3)(salH)] units in the complex are linked by an Ag–Ag bond. Whilst metal-free salH2 did not prevent the growth of the fungal pathogen Candida albicans [Ag2(NH3)2(salH)2], [Ag2(salH)2] and some simple Ag(I) salts greatly inhibited cell reproduction. SalH2, [Ag2(NH3)2(salH)2] [Ag2(salH)2] and AgClO4 produced a dose-dependent cytotoxic response against the three human derived cancer cell lines, Cal-27, Hep-G2 and A-498, with the Ag(I)-containing reagents being the most effective.

Item Type:	Article
Keywords:	Silver(I); Salicylate; X-ray structure; Anti-fungal; Anti-cancer;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	306
Identification Number:	https://doi.org/10.1016/j.jinorgbio.2004.04.016
Depositing User:	Dr. Kevin Kavanagh
Date Deposited:	01 Oct 2007
Journal or Publication Title:	Journal of Inorganic Biochemistry
Publisher:	Elsevier
Refereed:	Yes
URI:	http://www.elsevier.com/wps/find/journal...
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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