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    Cavitation rheology of the vitreous: mechanical properties of biological tissue

    Zimberlin, Jessica A. and McManus, Jennifer and Crosby, Alfred J. (2010) Cavitation rheology of the vitreous: mechanical properties of biological tissue. Soft Matter, 6. pp. 3632-3635. ISSN 1744-683X

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    We demonstrate the importance of measuring the mechanical properties of biological tissue in vivo by quantifying the mechanical properties of bovine vitreous both in its native state and upon removal from the eye. The mechanical properties are determined by the cavitation rheology technique developed in our labs to determine the linear modulus. This technique involves inducing a cavitation event at the tip of a syringe that is located at an arbitrary location within the vitreous sample. The pressure at which the cavitation event occurs can be directly related to the modulus. We show that the modulus decreases upon removal of the vitreous from the ocular cavity and decreases still further when the vitreous cortex, the thin membrane that surrounds the vitreous, is removed. This study has important implications for both diagnostic science of diseased tissue and developmental biology in studying tissue properties with age.

    Item Type: Article
    Additional Information: The definitive version of this article is available in Soft Matter Vol.6(2010) pp.3632-3635. DOI: 10.1039/B925407B
    Keywords: Cavitation; rheology; vitreous; mechanical properties; biological tissue;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 3835
    Depositing User: Jennifer McManus
    Date Deposited: 29 Aug 2012 15:42
    Journal or Publication Title: Soft Matter
    Publisher: Royal Society of Chemistry
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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