Zimberlin, Jessica A. and McManus, Jennifer and Crosby, Alfred J. (2010) Cavitation rheology of the vitreous: mechanical properties of biological tissue. Soft Matter, 6. pp. 3632-3635. ISSN 1744-683X

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Abstract

We demonstrate the importance of measuring the mechanical properties of biological tissue in vivo by quantifying the mechanical properties of bovine vitreous both in its native state and upon removal from the eye. The mechanical properties are determined by the cavitation rheology technique developed in our labs to determine the linear modulus. This technique involves inducing a cavitation event at the tip of a syringe that is located at an arbitrary location within the vitreous sample. The pressure at which the cavitation event occurs can be directly related to the modulus. We show that the modulus decreases upon removal of the vitreous from the ocular cavity and decreases still further when the vitreous cortex, the thin membrane that surrounds the vitreous, is removed. This study has important implications for both diagnostic science of diseased tissue and developmental biology in studying tissue properties with age.

Item Type:	Article
Additional Information:	The definitive version of this article is available in Soft Matter Vol.6(2010) pp.3632-3635. DOI: 10.1039/B925407B
Keywords:	Cavitation; rheology; vitreous; mechanical properties; biological tissue;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	3835
Depositing User:	Jennifer McManus
Date Deposited:	29 Aug 2012 15:42
Journal or Publication Title:	Soft Matter
Publisher:	Royal Society of Chemistry
Refereed:	Yes
URI:	http://pubs.rsc.org/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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