Coogan, Andrew and Thome, Johannes (2012) Editorial: Special Issue: circadian rhythms, clock genes and neuropsychiatry: interesting times. Journal of Neural Transmission, 119 (10). pp. 1059-1060. ISSN 0300-9564

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Abstract

Circadian rhythms are cycles in physiological, behavioural, psychological and other domains that recur approximately every 24 h. Such rhythms are driven by an endogenous circadian timekeeping system, whose molecular basis consists of the interlocking transcription and translation of a panel of "clock" genes, the expression of which then regulates gene expression and cellular function in a tissuespecific manner. Such rhythmic expression of clock genes is observed in most tissues, including the master circadian pacemaker in the suprachiasmatic nucleus of the hypothalamus, other CNS sites and peripheral organs. Therefore, the circadian system exerts considerable control over physiology and behaviour, and equally dysfunction of this circadian system may result in detrimental pathophysiological and psychopathological consequences.

Item Type:	Article
Additional Information:	The definitive version of this article is available at DOI 10.1007/s00702-012-0891-y
Keywords:	circadian rhythms; clock genes; neuropsychiatry;
Academic Unit:	Faculty of Science and Engineering > Psychology
Item ID:	4153
Depositing User:	Dr. Andrew Coogan
Date Deposited:	30 Jan 2013 16:55
Journal or Publication Title:	Journal of Neural Transmission
Publisher:	Springer Verlag
Refereed:	Yes
URI:	http://www.springer.com/medicine/neurolo...
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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