MURAL - Maynooth University Research Archive Library



    Conjugation at the oligonucleotide level based on isoxazole phosphoramidites generated by click chemistry


    Freeman, Colin and Ni Cheallaigh, Aisling and Heaney, Frances (2011) Conjugation at the oligonucleotide level based on isoxazole phosphoramidites generated by click chemistry. Tetrahedron, 67 (40). pp. 7860-7865. ISSN 0040-4020

    [img] Download (430kB)


    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...



    Add this article to your Mendeley library


    Abstract

    The versatility of the isoxazole generating nitrile oxide–alkyne Huisgen cycloaddition for provision of chemically modified oligonucleotides has been extended; in a novel approach isoxazole conjugated oligodeoxyribonucleotides have been constructed by phosphoramidite chemistry of isoxazole derivatives previously generated by nitrile oxide–alkyne click chemistry. The conjugation involves manual solid phase synthesis at room temperature in aqueous ethanol and proceeds in high yield.

    Item Type: Article
    Keywords: Conjugation; oligonucleotide; isoxazole phosphoramidites; click chemistry;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 4292
    Depositing User: Dr. Frances Heaney
    Date Deposited: 09 Apr 2013 10:07
    Journal or Publication Title: Tetrahedron
    Publisher: Elsevier
    Refereed: Yes
    URI:
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

    Repository Staff Only(login required)

    View Item Item control page

    Downloads

    Downloads per month over past year

    Origin of downloads