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Singh, Ishwar and Heaney, Frances (2010) Metal free, “click and click–click” conjugation of ribonucleosides and 2′-OMe oligoribonucleotides on the solid phase. Organic & Biomolecular Chemistry, 8 (3). pp. 451-456. ISSN 1477-0520
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Abstract
A fast and practical metal free conjugation of ribonucleosides and 2¢-OMe 4-mer oligoribonucleotides
has been accomplished by a nitrile oxide alkyne click cycloaddition reaction on the solid-phase, the
methodology is suited to modification at either, or both, the 3¢- or the 5¢-terminus of the
oligoribonucleotide substrate.
| Item Type: | Article |
|---|---|
| Keywords: | Metal free; “click and click–click” conjugation; ribonucleosides; 2′-OMe oligoribonucleotides; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 4293 |
| Depositing User: | Dr. Frances Heaney |
| Date Deposited: | 09 Apr 2013 10:37 |
| Journal or Publication Title: | Organic & Biomolecular Chemistry |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| Related URLs: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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